MHC class I in activity-dependent structural and functional plasticity
نویسندگان
چکیده
منابع مشابه
MHC class I in activity-dependent structural and functional plasticity.
Members of the major histocompatibility complex (MHC) class I family of proteins are well known for their central role in the adaptive immune system, where they present self and non-self peptides for immune surveillance. Although the brain has been long considered immune privileged, in part because of an apparent lack of neuronal MHC class I, it has since been shown that MHC class I proteins ar...
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Plasticity in the brain reaches far beyond a mere changing of synaptic strengths. Recent time-lapse imaging in the living brain reveals ongoing structural plasticity by forming or breaking of synapses, motile spines, and re-routing of axonal branches in the developing and adult brain. Some forms of structural plasticity do not follow Hebbian- or anti-Hebbian paradigms of plasticity but rather a...
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Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell's own translational machinery or that are funneled into the endo-lysosomal vesicular system. The prolonged interaction between a T cell receptor and specific pMHC complexes, after an ex...
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Observations from different brain areas have established that the adult nervous system can undergo significant experience-related structural changes throughout life. Less familiar is the notion that morphological plasticity affects not only neurons but glial cells as well. Yet there is abundant evidence showing that astrocytes, the most numerous cells in the mammalian brain, are highly mobile. ...
متن کاملFunctional requirement for class I MHC in CNS development and plasticity.
Class I major histocompatibility complex (class I MHC) molecules, known to be important for immune responses to antigen, are expressed also by neurons that undergo activity-dependent, long-term structural and synaptic modifications. Here, we show that in mice genetically deficient for cell surface class I MHC or for a class I MHC receptor component, CD3zeta, refinement of connections between re...
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ژورنال
عنوان ژورنال: Neuron Glia Biology
سال: 2004
ISSN: 1740-925X,1741-0533
DOI: 10.1017/s1740925x05000128